"It is time for us Clegg fans to echo those kindly folk who are trying to save the sweet furry badgers from the wrath of farmers," the mayor wrote.
"Never mind the badgers - save the Cleggster from extermination!"
Mr Johnson went on: "His wife, Miriam Gonzalez Durantez, is every bit as lovely and clever and funny as she appears.
"I have always thought that if you leave out Europe, he is probably a natural Tory.
"He is certainly tough, and can take a joke."
Mr Clegg was asked about the article on a visit to an engineering firm during the Lib Dem conference in Brighton.
"I actually haven't read it but I have heard about it," he replied.
"Boris is the nation's greatest celebrity politician and he is much held aloft by the people of London. He is an extremely amusing writer but I don't think I will be taking my guide from Boris about my own future.
"But I will read the article when I have some time to do so later in the afternoon."